A review article describing the history of bioelectricity and its link to the Nobel prize awarded to Willem Einthoven 100 years ago.

Volcanoes can be sleeping. When that happens, the ground only shakes very locally inside the volcano crater. However, when a volcanic eruption occurs, the ground trembles and shakes for miles away, having a much more global effect. This paper shows that a similar principle to the volcanic eruption can occur in the heart. Here local rhythm disturbances can suddenly wake up causing the whole heart to be affected globally.

A novel experimental technique making use of dynamic patch-clamp combined with real-time feedback computing.

It was previously shown how the heart itself could be enabled to detect and terminate arrhythmias thereby revealing the discovery of fully biological, shock-free cardioversion. This fully biological nature creates a new perspective for the termination of arrhythmia's when- or wherever. Increasing evidence suggests that patients may indeed benefit from such continuous real-time rhythm control, which is outlined in this work.

The heart is known to be prone to rhythm disturbances which have a detrimental effect on life. We have to rely on drugs, machinery or hospital interventions to get better. However, what if we could enable the heart to be a solution for its own problems? This study explores that hypothesis and comes up with an elegant solution that is in the end tested in a real heart cell.

Fat tissue infiltrates in the cardiac wall influence the surrounding cardiac cells by changing their electrical properties. The question remains however, what these changes mean for the occurrence and propagation of heart rhythm disorders. In this publication, I try to answer these questions by using computer simulations of the realistic three dimensional heart.

In previous studies, a correlation was shown between fat tissue infiltrates in the heart wall and the occurrence of heart rhythm disorders. But is this correlation perhaps also a causation? With the use of computer simulations and mathematical modeling, I try to answer this question.