Embedded Files
First author papers
EP Europace 2024 (De Coster, Nobacht et al.)
Cardiovasc Res 2024 (De Coster et al.)
Cell Reports Methods 2023 (Ördög, De Coster et al.)
eLife 2020 (Majumder, De Coster, Kudryashova et al.)
Frontiers 2018 (De Coster et al.)
Scientific Reports 2018 (De Coster et al.)
Master Thesis 2014 (De Coster)
Bachelor Thesis 2012 (De Coster & Gins)
Last author papers
Computer Physics Communications 2026 (Kabus, Dierckx, De Coster)
Advanced Science 2026 (Deng, ..., De Coster, Pijnappels)
eLife 2026 (Teplenin, ..., Pijnappels, De Coster)
Scientific Reports 2025 (De Coster)
AJP-Heart 2021 (De Coster)
[Pigreads: The Python-integrated GPU-enabled reaction-diffusion solver using OpenCL for cardiac electrophysiology and other applications]
A new software platform was created for fast, robust and cross-platform simulations using python.
[Smart Optogenetics for Real-Time Automated Control of Cardiac Electrical Activity]
Our work bridges the gap between observation and intervention of cardiac arrhythmias. It offers a powerful platform for exploring fundamental questions about rotor dynamics, optimal termination strategies, and feedback-driven rhythm stabilization. Thereby it forms a key step toward shock-free, intelligent arrhythmia therapies rooted in real-time bioelectronic control, reducing tissue damage and alleviating pain.
[Atypical collective oscillatory activity in cardiac tissue uncovered by optogenetics]
This work provides mechanistic insights into the development of cardiac arrhythmia and establishes a new experimental use case for optogenetics in studying cardiac electrophysiology. The agreement between computational models and experimental observations provides evidence that wave train-induced pacemaker activity can originate in continuously depolarized tissue.
[(Cardiac) Complexity needs Interaction]
An editorial describing the necessity for collaboration in todays cardiac reasearch landscape with a focus on some modern innovations.
[Monitoring and modulating Cardiac bioelectricity: from Einthoven to End-user]
A review article describing the history of bioelectricity and its link to the Nobel prize awarded to Willem Einthoven 100 years ago.
["Trapped reentry" as source of focal arrhythmias]
Volcanoes can be sleeping. When that happens, the ground only shakes very locally inside the volcano crater. However, when a volcanic eruption occurs, the ground trembles and shakes for miles away, having a much more global effect. This paper shows that a similar principle to the volcanic eruption can occur in the heart. Here local rhythm disturbances can suddenly wake up causing the whole heart to be affected globally.
[Opto-electronic feedback control of membrane potential for real-time (re)shaping of action potentials]
A novel experimental technique making use of dynamic patch-clamp combined with real-time feedback computing.
[A shock-free approach for ambulatory cardioversion in atrial fibrillation]
It was previously shown how the heart itself could be enabled to detect and terminate arrhythmias thereby revealing the discovery of fully biological, shock-free cardioversion. This fully biological nature creates a new perspective for the termination of arrhythmia's when- or wherever. Increasing evidence suggests that patients may indeed benefit from such continuous real-time rhythm control, which is outlined in this work.
[Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating]
The heart is known to be prone to rhythm disturbances which have a detrimental effect on life. We have to rely on drugs, machinery or hospital interventions to get better. However, what if we could enable the heart to be a solution for its own problems? This study explores that hypothesis and comes up with an elegant solution that is in the end tested in a real heart cell.
[Myocyte remodeling due to fibro-fatty infiltrations influences arrhythmogenicity]
Fat tissue infiltrates in the cardiac wall influence the surrounding cardiac cells by changing their electrical properties. The question remains however, what these changes mean for the occurrence and propagation of heart rhythm disorders. In this publication, I try to answer these questions by using computer simulations of the realistic three dimensional heart.
[Arrhythmogenicity of fibro-fatty infiltrations]
In previous studies, a correlation was shown between fat tissue infiltrates in the heart wall and the occurrence of heart rhythm disorders. But is this correlation perhaps also a causation? With the use of computer simulations and mathematical modeling, I try to answer this question.
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